Role of Nanotechnology in Erectile Dysfunction Treatment

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• 作者：Alice Y. Wang ; BS¹ ; Carol A. Podlasek ; PhD² ; ^{cap325@uic.edu}
• 关键词：Nanotechnology ; Hydrogel ; Cavernous Nerve ; Penis ; Erectile Dysfunction
• 刊名：The Journal of Sexual Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：14
• 期：1
• 页码：36-43
• 全文大小：219 K
• 卷排序：14

文摘

The biological importance of nanotechnology-based delivery vehicles for in vivo tissue regeneration is gaining acceptance by the medical community; however, its relevance and incorporation into the treatment of sexual dysfunction are evolving and have not been well evaluated.AimTo provide scientific evidence examining the use of state-of-the-art nanotechnology-based delivery methodology in the treatment of erectile dysfunction (ED) in animal models and in patients.MethodsThis review assessed the current basic science literature examining the role of nanotechnology-based delivery vehicles in the development of potential ED therapies.ResultsThere are four primary areas where nanotechnology has been applied for ED treatment: (i) topical delivery of drugs for on-demand erectile function, (ii) injectable gels into the penis to prevent morphologic changes after prostatectomy, (iii) hydrogels to promote cavernous nerve regeneration or neuroprotection, and (iv) encapsulation of drugs to increase erectile function (primarily of phosphodiesterase type 5 inhibitors).ConclusionBasic science studies provide evidence for a significant and evolving role for nanotechnology in the development of therapies for ED and suggest that properly administered nano-based therapies might be advantageous for treating male sexual dysfunction.