Long non-coding RNA NEAT1 facilitates pancreatic cancer progression through negative modulation of miR-506-3p

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• 作者：Bo Huang^a ; ¹ ; Chuan Liu^b ; ¹ ; Qiong Wu^a ; Jing Zhang^a ; Qinghua Min^a ; Tianle Sheng^b ; Xiaozhong Wang^a ; Yeqing Zou^b ; ^{zouyeqing3366@163.com}
• 关键词：Pancreatic cancer ; Cell proliferation ; LncRNA NEAT1 ; miR-506-3p
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：828-834
• 全文大小：1631 K
• 卷排序：482

文摘

Upregulation of NEAT1 expression was significantly associated with the poor survival in PC patients. Knockdown of NEAT1 can suppress PC cells growth by inducing cell cycle arrest and apoptosis promotion in vitro study. NEAT1 functions as an oncogene in pancreatic cancer by acting as a competing endogenous RNA for miR-506-3p. The tumor-suppressive effects of NEAT1 knockdown in PC cells was partially reversed by miR-506-3p inhibitor.