Genetic association between HLA class I alleles and hepatitis B virus-related hepatocellular carcinoma in a southern Chinese population

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• 作者：Minzhong Tang^a ; Yuming Zheng^a ; Yonglin Cai^a ; Xiaojiang Gao^b ; Mary Carrington^b ; Tao Peng^c
• 刊名：Human Immunology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：76
• 期：supp_S
• 页码：80
• 全文大小：42 K

文摘

Hepatocellular carcinoma (HCC) is a complex disease with multi-factorial in etiology. To investigate the association between HLA class I allele phenotypes and HCC, we have conducted a case-control study in a Chinese HCC cohort from a minority region in southern China.

Methods

HLA class I genes were molecularly typed in 329 individuals with HCC and 342 non-HCC matched controls with normal liver enzyme levels.

Results

Stratified analysis performed in the present study demonstrated that A^*0201 (odds ratio [OR], 0.34; P = 0.006), B^*3802 (OR, 1.87; P = 0.02) and Cw^*0401 (OR, 0.34; P = 0.02) were associated with HCC in Han Chinese; B^*1501 (OR, 0.09; P = 0.04), B^*4001 (OR, 0.33; P = 0.009), Cw^*0702 (OR, 0.53; P = 0.04) and Cw^*1402 (OR, 7.88; P = 0.02) were associated with HCC in Zhuang Chinese; B^*1527 (OR, 0.08; P = 0.005), B^*4001 (OR, 0.49; P = 0.01) and Cw^*0401 (OR, 0.19; P = 0.0003) have shown significant if only HBV positive was took into account.

Conclusion

The associations with class I alleles showed that particular HLA phenotypes are associated with varied HCC risks in different ethnic groups. Interestingly, Cw^*0401 was the only allele showing significance after correction and had been present in both Han ethnic group and Hepatitis B virus (HBV) positive group which has potential relationship to anti-tumor CTL or NK cell responses.

M. Carrington:Grant/Research Support; Company/Organization; This work was supported in part byUSA National Institutes of Health Grants(ES05116andES09089).T. Peng:Grant/Research Support; Company/Organization; This work was supported in part by theNational Nature Science Foundation of China(NSFC30460143,30560133,30760243), Ministry of Education (NCET Program in University 2009).