Joint acute and endocrine disruptive toxicities of malathion, cypermethrin and prochloraz to embryo-larval zebrafish, Danio rerio
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- 作者：Dongmei Guoa ; Yanhua Wangb ; Yongzhong Qiana ; qyzcaas@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Chen Chena ; Bining Jiaoc ; Leiming Caib ; Qiang Wangb ; Qiangwang2003@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Combined toxicity ; Zebrafish ; Hypothalamic-pituitary-gonadal axis ; Estrogen ; Gene expression
- 刊名：Chemosphere
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：166
- 期：Complete
- 页码：63-71
- 全文大小：1514 K
文摘
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According to 96 h-LC50 values, the order of toxicity was as follows: CPM > PRO > MAL.
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Binary mixture of MAL + CPM displayed a synergistic effect on the acute toxicity to zebrafish larvae, and MAL + PRO showed an antagonistic effect.
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Transcription of many key genes involved in the HPG axis was a significantly altered after exposure to MAL + CPM and MAL + PRO.