IL-8 interacts with metadherin promoting proliferation and migration in gastric cancer
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- 作者：Wenfeng Lia ; Shuangming Lina ; Wenhuan Lib ; Weijun Wangb ; Xueming Lib ; ncdxyfy_xuemingli@163.com" class="auth_mail" title="E-mail the corresponding author ; Dongbo Xua ; fmualfh_dbxu@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Gastric cancer ; IL-8 ; MTDH ; Invasion ; Prognosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：23 September 2016
- 年：2016
- 卷：478
- 期：3
- 页码：1330-1337
- 全文大小：2147 K
文摘
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IL-8 was commonly observed to be significantly up-regulated in gastric cancer.
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IL-8 was found to be able to be directly interacted with MTDH.
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MTDH can up-regulate IL-8 promoting EMT process.
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Blockage of IL-8-MTDH complex can abrogate the growth of gastric cancer cells in vitro and in vivo.