The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity
详细信息 查看全文
- 作者：Yohan Roulland1 ; Khalid Ouararhni2 ; Mladen Naidenov3 ; 9 ; Lorrie Ramos1 ; Muhammad Shuaib2 ; Sajad Hussain Syed1 ; 3 ; 10 ; Imtiaz Nizar Lone1 ; 3 ; Ramachandran Boopathi1 ; 3 ; Emeline Fontaine1 ; Gabor Papai4 ; Hiroaki Tachiwana5 ; Thierry Gautier1 ; Dimitrios Skoufias6 ; Kiran Padmanabhan7 ; Jan Bednar1 ; Hitoshi Kurumizaka5 ; Patrick Schultz4 ; Dimitar Angelov3 ; dimitar.anguelov@ens-lyon.fr" class="auth_mail" title="E-mail the corresponding author ; Ali Hamiche2 ; 8 ; hamiche@igbmc.fr" class="auth_mail" title="E-mail the corresponding author ; Stefan Dimitrov1 ; stefan.dimitrov@univ-grenoble-alpes.fr" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：18 August 2016
- 年：2016
- 卷：63
- 期：4
- 页码：674-685
- 全文大小：3709 K
文摘
- •
CENP-A nucleosomal ends are highly flexible in solution
- •
Dynamic CENP-A nucleosomal ends prevent H1 recruitment
- •
Flexibility of DNA ends allows active kinetochore complex assembly
- •
Open CENP-A nucleosomal structure is essential for its mitotic function