Alterations of motor cortical microcircuit in a depressive-like mouse model produced by light deprivation

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• 作者：Yun-Feng Zhang^a ; ^b ; ^{zhangyunfeng1983@163.com} ; Qi-Qin Li^a ; ^b ; Jia Qu^a ; ^b ; Cui-Min Sun^a ; ^b ; Yun Wang^a ; ^b ; ^c ; ^{yun.wang@mail.eye.ac.cn} ; ^{wangy62@gmail.com}
• 关键词：AP ; action potential ; CLIMB ; climbing ; epsp2/epsp1 ; paired pulse ratio ; EPSPs ; excitatory postsynaptic potentials ; FST ; forced swimming test ; IB ; intrinsically bursting ; IMMOB ; immobility ; L5 ; Layer V ; L5PCs ; layer V pyramidal cells ; LD ; light deprivation ; mPFC ; medial prefrontal cortex ; NA ; noradrenergic ; PAW ; pawing ; PBS ; phosphate-buffered saline ; PCs ; Pyramidal cells ; ROB ; rhythmic oscillatory bursting ; RSAD ; adapting regular-spiking ; RTR ; recovery test response ; RTR/epsp1 ; amplitude ratio o
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：26 January 2017
• 年：2017
• 卷：341
• 期：Complete
• 页码：79-94
• 全文大小：2152 K
• 卷排序：341

文摘

Light deprivation could produce a depressive behavioral phenotype in mice. The depressive behavioral phenotype was characterized by increased immobility and decreased locomotor activity. Light deprivation decreased burst firing neurons, suppressed neural excitability and reduced neural morphological complexity. Light deprivation decreased the probability of single connections formed by L5PCs. Light deprivation increased the synaptic strength and transmitter release probability of single L5PC connections.