Biosynthesis of Neocarazostatin A Reveals the Sequential Carbazole Prenylation and Hydroxylation in the Tailoring Steps
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- 作者：Sheng Huang1 ; Somayah Sameer Elsayed2 ; Meinan Lv1 ; Jioji Tabudravu2 ; Mostafa E. Rateb2 ; 4 ; Roland Gyampoh3 ; Kwaku Kyeremeh3 ; Rainer Ebel2 ; Marcel Jaspars2 ; Zixin Deng1 ; Yi Yu1 ; yu_yi@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Hai Deng2 ; h.deng@abdn.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：carbazole alkaloids ; biosynthesis ; prenyltransferase ; reconstitution ; P450 enzyme ; neocarazostatin A
- 刊名：Chemistry & Biology
- 出版年：2015
- 出版时间：17 December 2015
- 年：2015
- 卷：22
- 期：12
- 页码：1633-1642
- 全文大小：2164 K
文摘
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The biosynthetic gene cluster of neocarazostatin A was identified
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A new type of carbazole prenyltransferases, NzsG, was characterized
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The P450 enzyme NzsA catalyzing the last step of the biosynthesis was identified
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The biotransformation in the late stage of the biosynthesis was reconstituted
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