Short arm of chromosome 11 and sporadic Alzheimer's disease: Catalase and cathepsin D gene polymorphisms
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- 作者：Cristiano Capurso ; Vincenzo Solfrizzi ; Alessia D’ ; Introno ; Anna M. Colacicco ; Sabrina A. Capurso ; Luigia Bifaro ; Roberta Menga ; Andrea Santamato ; Davide Seripa ; Alberto Pilotto ; Antonio Capurso
- 关键词：Catalase − ; 262 C/T promoter gene polymorphism ; Cathepsin D exon 2 gene polymorphism ; Apolipoprotein E ; Alzheimer's disease ; Dementia
- 刊名：Neuroscience Letters
- 出版年：2008
- 出版时间：27 February 2008
- 年：2008
- 卷：432
- 期：3
- 页码：237-242
- 全文大小：106 K
文摘
Catalase (CAT) −262 C/T promoter (rs1001179), cathepsin D (CTSD) exon 2 (rs17571), and apolipoprotein E (APOE) gene polymorphisms were studied in 242 patients with sporadic Alzheimer's disease (AD) and 421 unrelated age-, sex-, and ethnically matched control subjects from Apulia (Southern Italy). No statistically significant differences in CAT rs1001179 and CTSD rs17571 genotype and allele distribution between AD cases and healthy controls were observed for the whole AD sample, and when AD group was categorized by age at onset in early- and late-onset AD subsets. Furthermore, we did not find any statistically significant differences in rates between CAT rs1001179 and CTSD rs17571 genotypes and AD controlling for APOE e4 allele status. Our data, at present, do not support a role of two gene polymorphisms of the short arm of the chromosome 11, the CAT rs1001179 and CTSD rs17571, as a possible susceptibility factors for sporadic AD.