Identification of gene markers in the development of smoking-induced lung cancer
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- 作者：Zhao Yanga ; b ; Bing Zhuanb ; Ying Yanb ; Simin Jianga ; Tao Wanga ; taowangtww@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ERCC1 ; excision repair cross-complementation group 1 ; NSCLC ; non-small cell lung cancer ; XRCC1 ; X-ray repair cross complementing group 1 ; CYP2A6 ; cytochrome P450 2A6 ; GSTM1 ; glutathione S-transferase mu1 ; CYP1A1 ; cytochrome P450 1A1 ; EGFR ; epidermal growth factor receptor ; DEGs ; differentially expressed genes ; PPI ; protein&ndash ; protein interaction ; GEO ; Gene Expression Omnibus ; GO ; Gene Ontology ; KEGG ; Kyoto Encyclopedia of Genes and Genomes ; DAVID ; Database for Annotation ; Visualization and In
- 刊名：Gene
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：576
- 期：1
- 页码：451-457
- 全文大小：959 K
文摘
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We screened 1923 DEGs between smokers with and without lung cancer.
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SVM model analysis indicated that the five features had potential diagnostic value.
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MAPK1, SRC, SMAD4, EEF1A1, TRAF2 and PLCG1 might function in lung cancer.