High concentration of trichlorfon (1 mM) disrupts axonal cytoskeleton and decreases the expression of plasticity-related proteins in SH-SY5Y cells

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• 作者：Laí ; s Silva Fernandes^a ; Guilherme Luz Emerick^b ; Rafaela Scalco Ferreira^a ; Neife Aparecida G. dos Santos^a ; Antonio Cardozo dos Santos^a ; ^{acsantos@fcfrp.usp.br}
• 关键词：Organophosphate-induced delayed neuropathy (OPIDN) ; Axonal growth ; Synaptogenesis ; Neurofilament ; Trichlorfon
• 刊名：Toxicology in Vitro
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：39
• 期：Complete
• 页码：84-92
• 全文大小：1061 K
• 卷排序：39

文摘

The neuronal model was retinoic-acid-stimulated SH-SY5Y neuroblastoma cells. Trichorfon downregulated the axonal-growth associated protein GAP-43. Trichorfon downregulated synaptic proteins (synapsin I and synaptophysin). Trichorfon downregulated the axonal cytoskeletal protein NF-200. Mipafox (neuropathic) and Paraoxon (non-neuropathic) had distinct effects on these proteins.