Crocin protects against doxorubicin-induced myocardial toxicity in rats through down-regulation of inflammatory and apoptic pathways
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- 作者：Nehal M. Elsherbinya ; Mohamed F. Salamab ; Eman Saidc ; emansaid@mans.edu.eg" class="auth_mail" title="E-mail the corresponding author ; eman-sa3eed@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Mohamed El-Sherbinyd ; Mohammed M.H. Al-Gayyara ; e
- 关键词：Crocin ; Doxorubicin ; Caspase-3 ; Electrocardiogram ; Interleukins ; Tumor necrosis factor (TNF)-α
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：5 March 2016
- 年：2016
- 卷：247
- 期：Complete
- 页码：39-48
- 全文大小：3020 K
文摘
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Crocin reduces oxidative load and enhances host antioxidant defenses.
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Crocin down-regulates pro-inflammatory mediators expression.
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Crocin inhibits doxorubicin-induced depletion of anti-inflammatory cytokines.
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Crocin reduces doxorubicin-induced apoptosis in myocardium.
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