Identification of proteins that are differentially expressed in brains with Alzheimer's disease using iTRAQ labeling and tandem mass spectrometry
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- 作者：Benito Minjareza ; 1 ; bminjarez@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Karla Grisel Calderó ; n-Gonzá ; leza ; karla_grises@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Ma. Luz Valero Rustarazob ; 2 ; mluz.valero@uv.es" class="auth_mail" title="E-mail the corresponding author ; Marí ; a Esther Herrera-Aguirrea ; maestherha2@yahoo.com.mx" class="auth_mail" title="E-mail the corresponding author ; Marí ; a Luisa Labra-Barriosa ; azu_car2000@yahoo.com.mx" class="auth_mail" title="E-mail the corresponding author ; Diego E. Rincon-Limasc ; d ; diego.rincon@neurology.ufl.edu" class="auth_mail" title="E-mail the corresponding author ; Manuel M. Sá ; nchez del Pinob ; 3 ; sandelpi@uv.es" class="auth_mail" title="E-mail the corresponding author ; Raul Menae ; 4 ; Juan Pedro Luna-Ariasa ; jpluna@cell.cinvestav.mx" class="auth_mail" title="E-mail the corresponding author ; jpluna@cinvestav.mx" class="auth_mail" title="E-mail the corresponding author ; jpluna2003@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer's disease ; AD ; NFT ; Neurofibrillary tangle ; NPs ; Neuritic plaques ; PHFs ; Paired helical filaments ; CSF ; Cerebrospinal fluid ; PBS ; Phosphate buffered saline ; GuHCl ; Guanidine hydrochloride ; ABC ; Ammonium bicarbonate ; TEAB ; Triethylammonium bicarbonate ; TCEP ; Tris-(2-carboxyethyl) phosphine ; MMTS ; Methyl methanethiosulfonate ; TFA ; Trifluoroacetic acid ; FA ; Formic acid ; CHAPS ; 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate hydrate ; ROS ; Reactive oxygen species ; MS/MS ; Tande
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：29 April 2016
- 年：2016
- 卷：139
- 期：Complete
- 页码：103-121
- 全文大小：3090 K
文摘
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AD affected pathways: ROS, stress responses, oxidative phosphorylation.
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Some proteins were validated using a Drosophila genetic approach.
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Sideroflexin and Phosphoglucomutase-1, two novel proteins connected with AD.