USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome
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- 作者：Meng Lin1 ; 4 ; 7 ; Zhiyao Zhao1 ; 7 ; Zhifen Yang3 ; 7 ; Qingcai Meng1 ; Peng Tan4 ; 6 ; Weihong Xie3 ; Yunfei Qin1 ; Rong-Fu Wang4 ; 5 ; 6 ; 8 ; rwang3@houstonmethodist.org" class="auth_mail" title="E-mail the corresponding author ; Jun Cui1 ; 2 ; cuij5@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：innate immune signaling ; type I interferon response ; TBK1 ubiquitination ; K33 ubiquitination ; USP38 deubiquitination ; TBK1 degradation
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：20 October 2016
- 年：2016
- 卷：64
- 期：2
- 页码：267-281
- 全文大小：5525 K
文摘
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USP38 negatively regulates type I interferon signaling in vitro and in vivo
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USP38 interacts with the active form of TBK1 through NLRP4
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USP38 cleaves K33-linked poly-ubiquitin chains of TBK1
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NLRP4 signalosome mediates K48-linked ubiquitination of TBK1 for degradation