TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy
详细信息 查看全文
- 作者：Tao Liu1 ; 5 ; Qin Tang1 ; 4 ; 5 ; Kunpeng Liu1 ; Weihong Xie2 ; Xin Liu1 ; Huishan Wang1 ; Rong-Fu Wang4 ; rwang3@houstonmethodist.org" class="auth_mail" title="E-mail the corresponding author ; Jun Cui1 ; 3 ; cuij5@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：AIM2 inflammasome ; TRIM11 ; protein degradation ; p62 ; selective autophagy
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：16 August 2016
- 年：2016
- 卷：16
- 期：7
- 页码：1988-2002
- 全文大小：5353 K
文摘
- class="listitem" id="list_ulist0010">
- class="label">•
TRIM11 negatively regulates AIM2 inflammasome activation in vitro and in vivo
- class="label">•
TRIM11 undergoes auto-polyubiquitination upon DNA stimulation
- class="label">•
Ubiquitinated TRIM11 recruits AIM2 to p62 and degrades AIM2 via selective autophagy