Xenopus RCOR2 (REST corepressor 2) interacts with ZMYND8, which is involved in neural differentiation

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• 作者：Wanli Zeng ; Qinghua Kong ; Chaocui Li ; Bingyu Mao
• 关键词：Xenopus ; RCOR2 ; ZMYND8 ; REST ; Neural differentiation
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2010
• 出版时间：16 April 2010
• 年：2010
• 卷：394
• 期：4
• 页码：1024-1029
• 全文大小：497 K

文摘

Regulation of neuronal gene expression is critical to nervous system development. REST (RE1-silencing transcription factor) regulates neuronal gene expression through interacting with a group of corepressor proteins including REST corepressors (RCOR). Here we show that Xenopus RCOR2 is predominantly expressed in the developing nervous system. Through a yeast two-hybrid screen, we isolated Xenopus ZMYND8 (Zinc finger and MYND domain containing 8) as an XRCOR2 interacting factor. XRCOR2 and XZMYND8 bind each other in co-immunoprecipitation assays and both of them can function as transcriptional repressors. XZMYND8 is co-expressed with XRCOR2 in the nervous system and overexpression of XZMYND8 inhibits neural differentiation in Xenopus embryos. These data reveal a RCOR2/ZMYND8 complex which might be involved in the regulation of neural differentiation.