Effect of testosterone and its aliphatic and aromatic dimers on DNA morphology

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• 作者：P. Chanphai ; D. Agudelo ; A.R. Vesper ; G. Bé ; rubé ; H.A. Tajmir-Riahi ; ^{heidar-ali.tajmir-riahi@uqtr.ca}
• 关键词：testosterone ; 17 β-hydroxy-4-androsten-3-one ; testosterone aliphatic dimer (alip) ; 4-(17 β-acetoxy-4-androsten-3-one-7α-yl)-but-2-enoic acid 4-(17 β-acetoxy-4-androsten-3-one-7α-yl)-but-2-enoyloxy-butyl ester ; testosterone aromatic dimer (arom) ; 4-(17β-acetoxy-4-androsten-3-one-7α-yl)-but-2-enoic acid 4-[4-(17β-acetoxy-4-androsten-3-one-7α-yl)-but-2-enoyloxymethyl]-benzyl ester ; FTIR ; fourier transform infrared ; TEM ; transmission electron microscopy
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：95
• 期：Complete
• 页码：850-855
• 全文大小：2213 K
• 卷排序：95

文摘

The effect of testosterone and its dimers on DNA morphology was studied here. Testosterone dimers form stronger conjugates with DNA than testosterone. Hydrophobic contacts are mainly observed in steroid-DNA adducts. Major DNA morphological changes were observed upon testosterone conjugation. Our study elucidates the nature of steroid-DNA interactions.