Loss of Ca2 +-permeable AMPA receptors in synapses of tonic firing substantia gelatinosa neurons in the chronic constriction injury model of neuropathic pain
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- 作者：Yishen Chena ; Victor A. Derkachb ; c ; 1 ; Peter A. Smitha ; 1 ; peter.a.smith@ualberta.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：CP-AMPAR ; Ca2 ; +-permeable AMPA receptor ; CI-AMPAR ; Ca2 ; +-impermeable AMPA receptor ; CCI ; chronic constriction injury (of sciatic nerve) ; NSFA ; non-stationary fluctuation analysis ; DRZ ; dorsal root entry zone
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：279
- 期：Complete
- 页码：168-177
- 全文大小：818 K
文摘
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Peripheral nerve injury decreases synaptic drive to inhibitory neurons in substantia gelatinosa.
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Decreased synaptic drive involves functional loss of Ca2 + permeable AMPA receptors.
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Injury decreases single channel conductance of AMPA receptors on inhibitory neurons.
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Injury increases single channel conductance of AMPA receptors on excitatory neurons.
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Findings are related to the etiology of neuropathic pain and to potential therapeutic approaches.