Defective lymphatic valve development and chylothorax in mice with a lymphatic-specific deletion of Connexin43

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• 作者：Stephanie J. Munger^a ; ^{sjmunger@email.arizona.edu} ; Michael J. Davis^b ; ^{davismj@health.missouri.edu} ; Alexander M. Simon^a ; ^{amsimon@email.arizona.edu}
• 关键词：Connexin ; Connexin43 ; Gap junction ; Lymphatic valve ; Valve development ; Chylothorax
• 刊名：Developmental Biology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：421
• 期：2
• 页码：204-218
• 全文大小：2341 K
• 卷排序：421

文摘

A lymphatic-specific deletion of Cx43 was made using a Lyve-1 Cre allele. Cx43∆LEC mice exhibit insufficient lymph transport, leaky valves, and chylothorax. Cx43∆LEC mice show delayed lymphatic valve initiation and reduced valve frequency. Cx43∆LEC mice display immature valves with incomplete elongation of valve leaflets. Cx43 is required in lymphatic endothelial cells for normal valve development.