Bioactive molecules derived from umbilical cord mesenchymal stem cells

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• 作者：Lipeng Bai ^{bailp1@126.com" class="auth_mail" title="E-mail the corresponding author} ; Danting Li ^{272386059@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Jie Li ^{yx983507581@sina.com" class="auth_mail" title="E-mail the corresponding author} ; Zhengzhong Luo ^{zhengzhongluo@163.com" class="auth_mail" title="E-mail the corresponding author} ; Shumin Yu ; ^{yayushumin@163.com" class="auth_mail" title="E-mail the corresponding author} ; Suizhong Cao ^{suizhongcao@126.com" class="auth_mail" title="E-mail the corresponding author} ; Liuhong Shen ^{shenlh@sicau.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Zhicai Zuo ^{zzcjl@126.com" class="auth_mail" title="E-mail the corresponding author} ; Xiaoping Ma ^{mxp886@sina.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ACTH ; adrenocorticotropic hormone ; aFGF ; acidic fibroblast growth factor ; Akt ; activation of protein kinase B ; ANG ; angiogenin ; ASCs ; adipose tissue-derived mesenchymal stem cells ; B7-H1 ; B7 homolog 1 ; BDNF ; brain-derived neurotrophic factor ; bFGF ; basic fibroblast growth factor ; BMSCs ; bone marrow-derived MSCs ; CCL ; chemokine (C-C motif) ligand ; CM ; conditioned medium ; CSF ; colony-stimulating factors ; CX3CL ; CX3C chemokine ligand ; CXCL ; chemokine (C-X-C motif) ligand ; EGF ; epidermal growth fact
• 刊名：Acta Histochemica
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：118
• 期：8
• 页码：761-769
• 全文大小：1410 K

文摘

Umbilical cord mesenchymal stem cells (UCMSCs) retain their intrinsic stem cell potential while at the same time displaying high proliferation rates, powerful differentiation capacity, and low immunogenicity. They can also secrete multiple bioactive molecules that exert specific physiological functions. Thus, UCMSCs represent excellent candidates for cell therapy in regenerative medicine and tissue engineering. Abundant preclinical research on different disease models has shown that UCMSCs can accelerate wound or nerve damage recovery and suppress tumor progression. In fact, UCMSCs are thought to possess a higher therapeutic potential than MSCs derived from other tissues. Increasing evidence suggests that the mechanism underlying UCSMCs efficacy depends mostly on cell secretions, in contrast to the early paradigm of cell replacement and differentiation. In this review, we discuss UCMSCs biological characteristics, their secretome-based therapeutic mechanism, and potential applications.