Candida albicans cell shaving uncovers new proteins involved in cell wall integrity, yeast to hypha transition, stress response and host-pathogen interaction
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- 作者：Ana Gil-Bonaa ; 1 ; Claudia Marcela Parra-Giraldoa ; 1 ; Marí ; a Luisa Herná ; ezb ; Jose Antonio Reales-Calderona ; Norma V. Solisc ; Scott G. Fillerc ; Lucia Monteolivaa ; luciamon@ucm.es" class="auth_mail" title="E-mail the corresponding author ; Concha Gila
- 关键词：Candida albicans ; Trypsin digestion ; Surface proteins ; Cell wall integrity ; Osmotic stress ; Oxidative stress
- 刊名：Journal of Proteomics
- 出版年：2015
- 出版时间：8 September 2015
- 年：2015
- 卷：127
- 期：part_PB
- 页码：340-351
- 全文大小：1305 K
文摘
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Two-fold more proteins were identified in hyphae (928) than in yeast (438).
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A higher number of GPI and cell wall proteins were detected on the hyphae surface.
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A phenotypic study of 17 mutants in uncharacterized surface proteins was performed.
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Ali1, Mci4 and 2 Orfs are relevant in stress resistance and dimorphic transition.
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Pst3, Tos1 and 2 Orfs are related to cell wall and host–cell interaction.