Seroprofiling at the Candida albicans protein species level unveils an accurate molecular discriminator for candidemia
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- 作者：Aida Pitarch ; apitavel@ucm.es" class="auth_mail" title="E-mail the corresponding author ; Cé ; sar Nombela ; Concha Gil
- 关键词：AU ; arbitrary units ; BSI ; bloodstream infection ; CI ; confidence interval ; CGD ; Candida Genome Database ; HCA ; hierarchical cluster analysis ; IC ; invasive candidiasis ; OR ; odds ratio ; PCA ; principal component analysis ; PMF ; peptide mass fingerprinting ; PTM ; post-translational modification ; ROC ; receiver-operating-characteristic ; SERPA ; serological proteome analysis
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：16 February 2016
- 年：2016
- 卷：134
- 期：Complete
- 页码：144-162
- 全文大小：2896 K
文摘
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A higher speciation of the C. albicans immunome in candidemia than in commensalism
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Only 43 protein species were differentially recognized by candidemia and control sera.
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High connectivity and modularity of antigenic species co-recognition networks in candidemia
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Seroprofiling at the protein species level revealed better predictors of candidemia.
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An accurate molecular discriminator for candidemia was developed and validated.