Human DNA repair disorders in dermatology: A historical perspective, current concepts and new insight

详细信息    查看全文

• 作者：Shinichi Moriwaki ; ^{der002@osaka-med.ac.jp" class="auth_mail" title="E-mail the corresponding author}Author Vitae
• 关键词：BER ; base excision repair ; COFS ; cerebro&ndash ; oculo&ndash ; facio-skeletal syndrome ; CPD ; cyclobutane pyrimidine dimers ; CS ; Cockayne syndrome ; FA ; Fanconi anemia ; GG-NER ; global genome repair ; NER ; nucleotide excision repair ; 6&ndash ; 4 PP ; pyrimidine (6&ndash ; 4) pyrimidone photoproducts ; ROS ; reactive oxygen species ; TC-NER ; transcription-coupled repair ; TLS ; translesion synthesis ; TTD ; trichothiodystrophy ; UV ; ultraviolet ; UVSS ; UV-sensitive syndrome ; UVSSA ; UV-stimulated scaffold protein A ; XP
• 刊名：Journal of Dermatological Science
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：81
• 期：2
• 页码：77-84
• 全文大小：1084 K

文摘

Products of DNA damage, such as cyclobutane pyrimidine dimers (CPDs) and pyrimidine (6-4) pyrimidone photoproducts (6-4 PPs), are continually formed in genomes after exposure to UV radiation. When these DNA damages remain unrepaired in essential DNA sites for prolonged periods, DNA replication and transcription are hampered or mutation is induced, which may cause cell death, cellular senescence, and carcinogenesis of the skin. To protect against such UV-induced DNA damage, living organisms nicely retain “DNA repair systems”, which can efficiently repair “harmful” DNA damage through precise mechanisms by the integrated functions of many proteins. In humans, the failure of DNA repair systems causes a variety of disorders. Dermatological conditions such as hereditary photodermatoses, xeroderma pigmentosum (XP) and Cockayne syndrome (CS) are caused by congenital functional defects in the nucleotide excision repair (NER) system or the translesion synthesis (TLS) system. In this review, we describe the historical progress, recent findings, and future prospects of studies of human diseases associated with DNA-repair defects.