Selective induction of P-glycoprotein at the CNS barriers during symptomatic stage of an ALS animal model

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• 作者：Gary N.Y. Chan ; Rebecca A. Evans ; David B. Banks ; Emily V. Mesev ; David S. Miller ; Ronald E. Cannon ; ^{cannon1@niehs.nih.gov}
• 关键词：ABC ; ATP-binding cassette ; ALS ; amyotrophic lateral sclerosis ; BBB ; blood-brain barrier ; BCRP ; breast cancer resistance protein ; BSCB ; blood-spinal cord barrier ; CNS ; central nervous system ; MRP2 ; multidrug resistance-associated protein 2 ; P-gp ; P-glycoprotein ; SOD1 ; superoxide dismutase 1
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：3 February 2017
• 年：2017
• 卷：639
• 期：Complete
• 页码：103-113
• 全文大小：3943 K
• 卷排序：639

文摘

Characterization of drug efflux transporters at the blood-brain and blood-spinal cord barriers in an ALS SOD1 rat model. P-glycoprotein transport activity and expression levels were increased at the CNS barriers in rats at the ALS symptomatic stage. P-glycoprotein induction can restrict CNS delivery of current and new ALS pharmacotherapies that are substrates for this transporter.