Identification of a new cyathane diterpene that induces mitochondrial and autophagy-dependent apoptosis and shows a potent in vivo anti-colorectal cancer activity
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- 作者：Luwei Hea ; 1 ; Junjie Hana ; 1 ; Baowei Lib ; Li Huangb ; Ke Maa ; Quan Chenb ; Xinzhong Liua ; Li Baoa ; Hongwei Liua ; liuhw@im.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fungal diterpene ; Cyathin Q ; Apoptosis ; Autophagy ; ATG5 cleavage ; ROS
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：23 March 2016
- 年：2016
- 卷：111
- 期：Complete
- 页码：183-192
- 全文大小：2533 K
文摘
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We revealed a new fungal diterpene named as cyathin Q.
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Cyathin Q suppressed the growth of HCT 116 and bax-deficiency HCT116 cells in vivo and in vitro.
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Apoptosis induction of cyathin Q is ROS-mediated.
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The anticancer activity of cyathin Q is dependent on mitochondria and autophagy-related apoptosis.