Direct Conversion of Human Fibroblasts into Neural Progenitors Using Transcription Factors Enriched in Human ESC-Derived Neural Progenitors

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• 作者：Pei-Shan Hou¹ ; ⁴ ; Ching-Yu Chuang¹ ; ² ; ⁴ ; Chan-Hsien Yeh¹ ; ⁴ ; Wei Chiang¹ ; Hsiao-Jung Liu¹ ; Teng-Nan Lin³ ; Hung-Chih Kuo¹ ; ² ; ^{kuohuch@gate.sinica.edu.tw}
• 关键词：cell fate conversion ; induced neural progenitors ; transcription factors ; disease modeling
• 刊名：Stem Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：8
• 期：1
• 页码：54-68
• 全文大小：5088 K
• 卷排序：8

文摘

iENPs can be converted from fibroblasts using hESC-ENP enriched factors iENPs exhibit cellular and molecular characteristics resembling hESC-ENPs iENPs induced by different TF combinations exhibit different neural propensity iENP and their neuronal derivatives recapitulated HD and AD phenotypes