Ang-1 and Ang-2 expression in angiomyolipoma and PEComa family tumors

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• 作者：Swati Shrestha^a ; Carolyn Meyers^b ; Jia Shen^a ; Paulina Giacomelli^a ; Michelle A. Scott^c ; Chia Soo^d ; ^e ; Sarah M. Dry^b ; Kang Ting^a ; Aaron W. James^b ; ^d ; ^{Awjames@jhmi.edu}
• 关键词：Angiopoietin ; Perivascular epithelioid cell tumor ; Angiomyolipoma ; Pericyte ; PEComa ; Lymphangiomyoma
• 刊名：Journal of Orthopaedics
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：14
• 期：1
• 页码：154-160
• 全文大小：7842 K
• 卷排序：14

文摘

Perivascular epithelioid cell tumors (PEComa) are an uncommon family of soft tissue tumors. Previously, we described that the presence of pericyte antigens among PEComa family tumors differs extensively by histologic appearance.MethodsHere, we extend our findings using the pericyte antigens Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2), using immunohistochemical detection in human tumor samples.ResultsWhile Ang-1 showed no expression across any PEComa family tumor, Ang-2 showed expression that like other pericyte markers was largely determined by cytologic appearance.Conclusion/implicationsPericytic marker expression in PEComa may represent a true pericytic cell of origin, or alternatively aberrant pericyte marker adoption.