Age and severe adverse drug reactions caused by nifedipine and verapamil

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• 作者：Pahor ; Marco ; Manto ; Andrea ; Pedone ; Claudio ; Carosella ; Luciana ; Guralnik ; Jack M. ; Carbonin ; Pierugo
• 关键词：Adverse drug reactions ; calcium antagonists ; nifedipine ; verapamil ; age ; comorbidity
• 刊名：Journal of Clinical Epidemiology
• 出版年：1996
• 出版时间：August, 1996
• 年：1996
• 卷：49
• 期：8
• 页码：921-928
• 全文大小：1.05 M

文摘

The association of age with risk for severe adverse drug reactions (SADRs) was studied in 2371 and 862 hospitalized patients taking nifedipine and verapamil, respectively. Nifedipine caused hypotension (n = 22), tachycardia (n = 3), and acute renal failure (n = 1) (total SADR rate, 1.1 % , ). Verapamil caused hypotension (n = 3), bradycardia (n = 9), and atrioventricular blocks (n = 2) (total SADR rate 1.6 % ). The mean age of patients with and without SADRsr nifedipine 77.1 ± 1.7 71.8 ± 0.8 years, respectively (p < 0.05), and for verapamil 73.4 ± 2.9 and 73.1 ± 0.4 years, respectively. and Sex, length of stay, comorbidity, polypharmacy, intake of slow-release preparations, daily dosage, and new intake of calcium antagonists were examined as potential confounders of the age-SADR association. After adjusting for potential confounders, age was signficantly and independently associated with SADRs caused by nifedipine, but not with SADRs caused by verapamil (OR = 1.69, 95 % CI = 1.05–2.72 and OR = 1.06, 95 % 1.063–1.68 for 10-year increase, respectively). Although nifedipine and verapamil did not have significantly different rates of SADRs, an age-related gradient was found only for nifedipine.