Multidrug and toxin extrusion proteins mediate cellular transport of cadmium

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• 作者：Hong Yang^a ; Dong Guo^a ; Obinna N. Obianom^a ; Tong Su^b ; James E. Polli^a ; Yan Shu^a ; ^{yshu@rx.umaryland.edu}
• 关键词：Multidrug and toxin extrusion protein ; Cadmium ; Transporter ; Toxicity ; Detoxification ; Kidney
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：314
• 期：Complete
• 页码：55-62
• 全文大小：464 K
• 卷排序：314

文摘

Cadmium is an environmentally prevalent toxicant. Little was known regarding the elimination and detoxification of cadmium. Cadmium ion is here demonstrated as a substrate of MATE transporters. MATEs may function as cellular elimination machinery in cadmium detoxification.