Childhood Immune Thrombocytopenic Purpura: Diagnosis and Management

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• 作者：Victor Blanchette ; FRCP^a ; ^{victor.blanchette@sickkids.ca} ; Paula Bolton-Maggs ; DM ; FRCP^b
• 关键词：Immune thrombocytopenic purpura ; Immunoglobulin G ; Intravenous anti-D ; Combined cytopenias ; Splenectomy
• 刊名：Hematology/Oncology Clinics of North America
• 出版年：2010
• 出版时间：February 2010
• 年：2010
• 卷：24
• 期：1
• 页码：249-273
• 全文大小：839 K

文摘

Immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by a low circulating platelet count caused by destruction of antibody-sensitized platelets in the reticuloendothelial system. ITP can be classified as childhood versus adult, acute versus chronic, and primary versus secondary. Persistence of thrombocytopenia defines the chronic form of the disorder. Secondary causes of ITP include collagen vascular disorders, immune deficiencies, and some chronic infections. This review focuses on the diagnosis and management of children who have acute and chronic ITP. Emphasis is placed on areas of controversy and new therapies.