Tetrachlorobenzoquinone exhibits neurotoxicity by inducing inflammatory responses through ROS-mediated IKK/IκB/NF-κB signaling
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- 作者：Juanli Fu ; Qiong Shi ; Xiufang Song ; Xiaomin Xia ; Chuanyang Su ; Zixuan Liu ; Erqun Song ; Yang Song ; songyangwenrong@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; ysong@swu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：COX-2 ; cyclooxygenase-2 ; ELISA ; enzyme-linked immunosorbent assay ; EMSA ; electrophoretic mobility shift assay ; ERK1/2 ; extracellular regulated kinase1/2 ; HCB ; hexachlorobenzene ; IκBα ; inhibitor of NF-κB ; IKK ; inhibitor of nuclear factor kappa-B kinase ; IL-1β ; interleukin-1beta ; IL-6 ; interleukin-6 ; iNOS ; inducible nitric oxide synthase ; JNK ; c-Jun N-terminal kinase ; MAPK ; mitogen-activated protein kinases ; NAC ; N-acetyl-l-cysteine ; NF-κB ; nuclear factor-kappa B ; NO ; nitric oxide ; PCP ; pentachlor
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：41
- 期：Complete
- 页码：241-250
- 全文大小：2213 K
文摘
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TCBQ exhibits neurotoxicity by inducing inflammatory responses.
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TCBQ showed the highest capacity on inflammatory responses.
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TCBQ induces inflammatory responses through IKK/IκB/NF-κB signaling pathway.
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TCBQ-induced inflammatory responses are ROS-dependent.