Both BBR and 8-BBR-C16 have potential anti-atherosclerosis effects in WT diet induced ApoE−/− mice. Both BBR and 8-BBR-C16 inhibit oxidation and inflammation cytokine expressions. BBR and 8-BBR-C16 inhibit the translocation of NF-κB to the nucleus. 8-BBR-C16 is more efficient in treating atherosclerosis in ApoE−/− mice than BBR.