Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse
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- 作者：Ye Zhang1 ; 7 ; zhangye@stanford.edu" class="auth_mail" title="E-mail the corresponding author ; Steven A. Sloan1 ; 7 ; Laura E. Clarke1 ; Christine Caneda1 ; Colton A. Plaza1 ; Paul D. Blumenthal2 ; Hannes Vogel3 ; Gary K. Steinberg4 ; Michael S.B. Edwards4 ; Gordon Li4 ; John A. Duncan III5 ; Samuel H. Cheshier4 ; Lawrence M. Shuer4 ; Edward F. Chang6 ; Gerald A. Grant4 ; Melanie G. Hayden Gephart4 ; Ben A. Barres1
- 刊名：Neuron
- 出版年：2016
- 出版时间：6 January 2016
- 年：2016
- 卷：89
- 期：1
- 页码：37-53
- 全文大小：7161 K
文摘
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We develop the first method to acutely purify fetal and adult human astrocytes
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We obtain transcriptome profiles of human neurons, glia, and vascular cells
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While similar, human and mouse astrocytes have unique genomic and functional traits
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Human astrocytes exist in at least two distinct developmental stages
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