Autophagy during cardiac remodeling
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- 作者：Kazuhiko Nishida ; kazuhiko.nishida@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Kinya Otsu
- 关键词：AMPK ; AMP-activated protein kinase ; Atg ; autophagy-related protein ; CryABR120G ; a missense mutation of R120G in the αB-crystallin gene ; DAMP ; danger-associated molecular pattern ; DNase ; deoxyribonuclease ; DRC ; desmin-related cardiomyopathy ; FoxO ; forkhead box class O ; HIF-1α ; hypoxia-inducible factor 1α ; I/R ; ischemia/reperfusion ; LAMP2 ; lysosome-associated membrane protein 2 ; LC3 ; microtubule-associated protein 1 light chain 3 ; LV ; left ventricular or left ventricle ; LVAD ; LV assist device ; MI
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：11-18
- 全文大小：549 K
文摘
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Autophagy is important for the quality control of proteins and organelles.
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Autophagy is essential to maintain cellular homeostasis in the heart.
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Cardiac remodeling is a chronic maladaptive process.
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Autophagy is a cardioprotective mechanism during cardiac remodeling.
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Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure.
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