Endoplasmic reticulum and lysosomal Ca2+ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts
详细信息 查看全文
- 作者：Bethan S. Kilpatricka ; bethan.kilpatrick.10@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Joana Magalhaesb ; Michelle S. Beavanb ; Alisdair McNeillb ; Matthew E. Geggb ; Michael W.J. Cleeterb ; Duncan Bloor-Youngc ; Grant C. Churchillc ; Michael R. Duchena ; Anthony H. Schapirab ; Sandip Patela ; patel.s@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：ER ; endoplasmic reticulum ; cADPR ; cyclic ADP-ribose ; SERCA ; sarco-endoplasmic reticulum Ca2+ ATPase ; PD ; Parkinson disease ; GD ; Gaucher disease ; ASX ; asymptomatic ; CBE ; conduritol B epoxide ; GPN ; glycyl-l-phenylalanine 2-naphthylamide ; LAMP ; lysosome associated membrane protein ; LC3 ; microtubule-associated protein 1A/1B-light chain 3
- 刊名：Cell Calcium
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：59
- 期：1
- 页码：12-20
- 全文大小：2724 K
文摘
- •
ER Ca2+ signalling is potentiated in PD patient fibroblasts.
- •
Lysosomal Ca2+ signalling is inhibited in PD patient fibroblasts.
- •
Remodelling of Ca2+ stores is age-dependent.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |