Impact of R264C and R264H polymorphisms in human aromatase function

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• 作者：Roberta Baravalle^a ; ¹ ; Giovanna Di Nardo^a ; ^b ; ¹ ; Andrea Bandino^c ; Ines Barone^d ; Stefania Catalano^d ; Sebastiano Andò ; ^d ; Gianfranco Gilardi^a ; ^b ; ^{gianfranco.gilardi@unito.it}
• 关键词：Human aromatase ; SNPs ; Phosphorylation ; ST14A neuronal cells ; MCF-7 breast cancer cells
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：23-32
• 全文大小：1331 K
• 卷排序：167

文摘

Human aromatase polymorphisms in R264 alter its catalytic efficiency. R264 polymorphisms alter the consensus for phosphorylation by PKA/PKG on S267/T268. In MCF-7 cells, the polymorphic variants show different activities compared to wild-type. In neuronal progenitors, the activity of the polymorphic variants is similar to wild-type.