Increased neuronal and astroglial aquaporin-1 immunoreactivity in rat striatum by chemical preconditioning with 3-nitropropionic acid
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- 作者：Akihiko Hoshia ; hoshia@fmu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Ayako Tsunodaa ; Teiji Yamamotoa ; Mari Tadab ; Akiyoshi Kakitab ; Yoshikazu Ugawaa
- 关键词：Astrocyte ; Neuron ; Reactive astrocytosis ; Water homeostasis
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：28 July 2016
- 年：2016
- 卷：626
- 期：Complete
- 页码：48-53
- 全文大小：2418 K
文摘
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Aquaporin-1 (AQP1) is a water channel expressed in the choroid plexus.
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Reactive astrocytes also express AQP1 under some pathological conditions.
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3-Nitropropionic acid (3NP) is a neurotoxin that causes degeneration of striatum.
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AQP1 was expressed in astroglia and neurons of rat striatum after 3NP treatment.
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Induced AQP1 may play a pivotal role in water homeostasis in the striatum.