Valproic acid ameliorates olfactory dysfunction in APP/PS1 transgenic mice of Alzheimer's disease: Ameliorations from the olfactory epithelium to the olfactory bulb
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- 作者：Zhi-Gang Yaoa ; Hai-Yan Jinga ; Dong-Mei Wangb ; Bei-Bei Lva ; Jia-Mei Lia ; Feng-Feng Liua ; Hui Fana ; Xi-Chao Suna ; Ye-Jun Qina ; 1 ; Miao-Qing Zhaoa ; 1
- 关键词：Amyloid β ; APP/PS1 transgenic mice ; Alzheimer's disease ; Olfactory system
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：53-59
- 全文大小：1172 K
文摘
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Valproic acid (VPA) improved olfactory dysfunction in APP/PS1 transgenic mice of Alzheimer's disease.
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The mechanisms relied on the reduced amyloid β (Aβ) burden and ameliorated degenerative changes in the olfactory epithelium (OE) and olfactory bulb (OB).
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VPA may provide a new therapeutic strategy for the treatment of olfactory dysfunction in AD patients.