Pegylated interferons for chronic hepatitis B

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• 作者：Craxi ; Antonio ; Cooksley ; W. Graham
• 关键词：Peginterferon alpha-2a (40kDa) ; Chronic hepatitis B ; Interferon alpha
• 刊名：Antiviral Research
• 出版年：2003
• 出版时间：October, 2003
• 年：2003
• 卷：60
• 期：2
• 页码：87-89
• 全文大小：52.8 K

文摘

Conventional interferon therapy has been used for the treatment of chronic hepatitis B (CHB) for many decades. However, the use of interferon has been limited by its short half-life and high incidence of dose-related side effects. A meta-analysis investigating the short- and long-term consequences of interferon therapy showed that, whilst interferon therapy was beneficial in the short term, resulting in normalization of alanine aminotransferase (ALT) levels, loss of HBeAg, ‘e’ seroconversion and suppression of hepatitis B virus (HBV) DNA, the long-term benefits were less substantial.