TNF-alpha gene polymorphism and TNF-alpha levels in obese Asian Indians with obstructive sleep apnea

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• 作者：Bharat Bhushan ; R ; eep Guleria ; Anoop Misra ; Kalpana Luthra ; Naval K. Vikram
• 关键词：Obstructive sleep apnea ; Tumor necrosis factor-α ; Gene polymorphism ; Asian Indians ; Obesity
• 刊名：Respiratory Medicine
• 出版年：2009
• 出版时间：March 2009
• 年：2009
• 卷：103
• 期：3
• 页码：386-392
• 全文大小：165 K

文摘

Summary

Background

Obstructive sleep apnea (OSA) is emerging as a significant disorder in India. Tumor necrosis factor-α (TNFα) is an important marker of inflammation. Recent data indicate that inflammation may be an important correlate of OSA. The relationships of OSA with TNFα levels and TNFα gene promoter polymorphism (−308G/A) have not been investigated in obese Asian Indians with OSA.

Objective

To look for the correlation if any, between TNFα gene promoter polymorphism (−308G/A) in obese Asian Indians with and without OSA and correlation of TNFα levels with severity of OSA.

Methods and results

We studied 207 obese (BMI > 25 kg/m²) subjects; 104 with OSA and 103 without OSA. Both groups were matched for age, body mass index (BMI) and percentage body fat ( % BF). Measurements included anthropometric and biochemical (fasting blood glucose, lipid profile and serum TNFα levels) parameters and TNFα gene promoter polymorphism (−308G/A). The frequency of ‘−308A’ allele in TNFα gene was significantly higher in obese subjects with OSA (28.8 % ; 60/208), when compared with obese subjects without OSA (12.6 % ; 26/206, p = 0.001). Serum TNFα levels were significantly higher in obese subjects with OSA [(3.6 ± 0.8)pg/ml], when compared with obese subjects without OSA [(3.3 ± 0.6)pg/ml, p = 0.009].

Conclusions

Frequency of TNFα (−308A) allele and serum TNFα level was significantly higher in obese Asian Indians with OSA.