Gender Differences in Locomotor and Stereotypic Behavior Associated With l-Carnitine Treatment in Mice

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• 作者：Salvatore Benvenga MD¹ ; ² ; ³ ; ^{s.benvenga@me.nettuno.it} ; Elenora Itri MD¹ ; Peter Hauser MD⁴ ; Louis De Tolla VMD ; PhD⁵ ; Sui-Foh Yu VMD ; PhD⁵ ; Giuseppe Testa BA ; MA⁶ ; Maria Angela Pappalardo MD¹ ; Francesco Trimarchi MD¹ ; Antonino Amato MD⁶
• 关键词：gender differences ; l-carnitine ; locomotor activity ; stereotypic activity
• 刊名：Gender Medicine
• 出版年：2011
• 出版时间：February 2011
• 年：2011
• 卷：8
• 期：1
• 页码：1-13
• 全文大小：1489 K

文摘

Background

The carnitines exert neuroprotective and neuromodulatory actions, and carnitine supplementation increases locomotor activity (LMA) in experimental animals.

Methods

We measured 13 indexes of LMA and 3 indexes of stereotypic activity (STA) in adult male and female caged mice. In a randomized 4-week trial, 10 males and 10 females received 50 mg/kg body weight PO l-carnitine, and another 10 males and 10 females received placebo.

Results

Compared with placebo-treated females, placebo-treated males had a greater number of stereotypies (NSTs), stereotypy counts (STCs), stereotypy time (STT), and right front time (RFT), but smaller total distance traveled (TDT), margin distance (MD), number of vertical movements (NVMs), and left rear time (LRT). Compared with placebo-treated males, carnitine-treated males had greater horizontal activity (HA), movement time (MT), NVM, STT, TDT, STC, MD, LRT, and clockwise revolutions (CRs), but smaller left front time (LFT) and RFT. Compared with placebo-treated females, carnitine-treated females had greater NST, STC, STT, LFT, and RFT, but smaller NM, HA, NVM, VA, MT, anticlockwise revolutions (ACRs), CR, TDT, and MD; right rear time (RRT) remained statistically insignificant across all comparisons.

Conclusions

In summary, l-carnitine caused gender differences to persist for STC, diminish for NST and STT, disappear for LRT and NVM, change in the opposite direction for TDT and MD, appear de novo for HA, VA, NM, MT, and LFT, and remain absent for RRT and ACR. Some indexes of LMA and STA are sexually dimorphic in adult mice, and l-carnitine differentially maintains, diminishes/cancels, inverts, or creates the sexual dimorphism of particular indexes.