Neuroprotective effects of N-adamantyl-4-methylthiazol-2-amine against amyloid β-induced oxidative stress in mouse hippocampus

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• 作者：Jiae Kim^a ; Chang Hun Cho^a ; Hoh-Gyu Hahn^b ; Soo-Young Choi^c ; Sung-Woo Cho^a ; ^{swcho@amc.seoul.kr}
• 关键词：Aβ ; amyloidβ ; AD ; Alzheimer&rsquo ; s disease ; cPLA2 ; cytosolic phospholipase A2 ; DCF ; DA 2&prime ; 7&prime ; -dichlorofluorescin diacetate ; CAT ; catalase ; DMSO ; dimethyl-sulfoxide ; EDTA ; ethylenediaminetetraacetic acid ; GPx ; glutathione peroxidase ; GSH ; reduced glutathione ; HO-1 ; heme oxygenase 1 ; IL-1β ; Interleukin-1 beta ; iNOS ; including nitric oxide synthase ; MDA ; malondialdehyde ; MMP-2 ; matrix metalloproteinase-2 ; Nrf2 ; nuclear factor-erythroid 2-related factor 2 ; ROS ; reactive oxygen species ; S
• 刊名：Brain Research Bulletin
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：128
• 期：Complete
• 页码：22-28
• 全文大小：1290 K
• 卷排序：128

文摘

KHG26693 attenuated Aβ-induced oxidative stress in the hippocampus of mice. KHG26693 attenuated Aβ-induced TNF-α and IL-1β enhancements. KHG26693 attenuated Aβ-induced protein oxidation and reactive oxygen species. KHG26693 attenuated Aβ-induced MMP-2, cPLA2, and pcPLA2 expressions. KHG26693 attenuated Aβ-induced Nrf2 and HO-1 expressions.