Desmoplasia suppression by metformin-mediated AMPK activation inhibits pancreatic cancer progression

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• 作者：Wanxing Duan^a ; Ke Chen^a ; Zhengdong Jiang^a ; Xin Chen^a ; Liankang Sun^a ; Jiahui Li^a ; Jianjun Lei^a ; Qinhong Xu^a ; Jiguang Ma^b ; Xuqi Li^c ; Liang Han^a ; Zheng Wang^a ; Zheng Wu^a ; Fengfei Wang^d ; Erxi Wu^d ; ^e ; ^f ; Qingyong Ma^a ; ^{qyma56@mail.xjtu.edu.cn} ; Zhenhua Ma^a ;
• 关键词：AMP-activated protein kinase (AMPK) ; Metformin ; Pancreatic cancer ; Desmoplastic reaction ; Pancreatic stellate cells (PSCs)
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：385
• 期：Complete
• 页码：225-233
• 全文大小：3047 K
• 卷排序：385

文摘

Reduced P-AMPK expression is a frequent event in PDAC and correlated with poor prognosis and the dense stromal reaction. Metformin induced AMPK activation in pancreatic cancer cells leads to reduced production of fibrogenic cytokines. Metformin enhances the antitumor effect of gemcitabine.