Study on the propylphosphonic anhydride (T3P^®) mediated Ugi-type three-component reaction. Efficient synthesis of an α-amino amide library

详细信息    查看全文

• 作者：Má ; tyá ; s Milen ; ^{milen.matyas@egis.hu} ; Andrá ; s Dancsó ; Tamá ; s Fö ; ldesi ; Balá ; zs Volk
• 关键词：Multicomponent reaction ; Three-component Ugi reaction ; α-Amino amides ; T3P® ; Mechanism
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：73
• 期：1
• 页码：70-77
• 全文大小：508 K
• 卷排序：73

文摘

In the present work, a mild and simple synthesis of α-amino amides has been developed via the one-pot three-component ABC type Ugi reaction of a wide variety of aromatic aldehydes and primary aromatic amines, and two different aliphatic isocyanides. The reactions took place rapidly at room temperature in the presence of 1-propanephosphonic acid cyclic anhydride (T3P®), rendering possible the highly efficient preparation of an α-amino amide library in medium to excellent yields. This study represents the first case in which T3P® has been used in the Ugi reaction.