Cigarette smoke and related risk factors in neurological disorders: An update

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• 作者：Smilin Bell Aseervatham G^a ; Sangdun Choi^b ; Jayalakshmi Krishnan^c ; Ruckmani K^a ; ^{hodpharma@gmail.com}
• 关键词：Cigarette smoke ; Alzheimer&rsquo ; s disease ; Ischemic stroke ; Oxidative stress ; Neurodegeneration
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：85
• 期：Complete
• 页码：79-86
• 全文大小：1265 K
• 卷排序：85

文摘

Cigarette smoking is known to be harmful to health, and is considered the main cause of death worldwide, especially in India. Among the well-distinguished diseases related to smoking are, chronic obstructive pulmonary disease, oral and peripheral cancers, and cardiovascular complications. However, the impact of cigarette smoking on neurocognitive and neuropathological effects, including anxiety, Alzheimer’s disease, Parkinson’s disease, ischemic stroke, and blood-brain barrier dysfunction, still remains unclear. Cigarette smoke consists of more than 4500 toxic chemicals that combine to form free radicals, which lead to oxidative stress-associated neurological disorders. Herein, we discuss the role of antioxidant agents in delaying or attenuating disease complications. In addition, in this review, we discuss the neuropathological effect of cigarette smoke and its interference in neurodegeneration.