Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury

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• 作者：Dearbhaile Dooley¹ ; ² ; Evi Lemmens¹ ; Tim Vangansewinkel¹ ; Debbie Le Blon² ; Chloé ; Hoornaert² ; Peter Ponsaerts² ; ³ ; Sven Hendrix¹ ; ³ ; ^{sven.hendrix@uhasselt.be}
• 关键词：mesenchymal stem cells ; interleukin-13 ; spinal cord injury ; cell transplantation ; microglia ; macrophages
• 刊名：Stem Cell Reports
• 出版年：2016
• 出版时间：13 December 2016
• 年：2016
• 卷：7
• 期：6
• 页码：1099-1115
• 全文大小：7106 K
• 卷排序：7

文摘

Use of MSCs as carriers of IL-13 in a mouse model of SCI IL-13-secreting MSCs improve functional and histopathological outcome after SCI Increase in number of alternatively activated macrophages in MSC/IL-13-treated mice Decrease in macrophage-axon contacts in MSC/IL-13-treated mice