Transgenerational impairment of hippocampal Akt-mTOR signaling and behavioral deficits in the offspring of mice that experience postpartum depression-like illness

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• 作者：Ruyan Wu^a ; ^b ; Hailou Zhang^a ; Wenda Xue^a ; Zhilu Zou^a ; Cai Lu^c ; Baomei Xia^a ; Wei Wang^d ; Gang Chen^a ; ^{chengang@njucm.edu.cn}
• 关键词：Postpartum depression ; Offspring ; Akt-mTOR ; Transgeneration ; Depression-like behaviors ; Disc1
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2017
• 出版时间：6 February 2017
• 年：2017
• 卷：73
• 期：Complete
• 页码：11-18
• 全文大小：895 K
• 卷排序：73

文摘

PPD-F1 showed depression-like behaviors and hippocampal Akt-mTOR signaling deficiency at juvenile and adult stages. A single dose of ketamine reversed the behavior deficits and the impairment in Akt-mTOR signaling in PPD-F1. PPD-F2 mice remained deficient in the SP and NSF test and hippocampal Akt-mTOR signaling.