Regulation of Serine-Threonine Kinase Akt Activation by NAD⁺-Dependent Deacetylase SIRT7

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• 作者：Jia Yu¹ ; ⁷ ; Bo Qin¹ ; ² ; ⁷ ; Fengying Wu³ ; Sisi Qin¹ ; Somaira Nowsheen⁴ ; Shan Shan⁵ ; Jacqueline Zayas⁴ ; Huadong Pei² ; ⁶ ; Zhenkun Lou² ; ^{lou.zhenkun@mayo.edu} ; Liewei Wang¹ ; ⁸ ; ^{wang.liewei@mayo.edu}
• 关键词：SIRT7 ; Akt signaling pathway ; breast cancer ; chemo-sensitivity
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：31 January 2017
• 年：2017
• 卷：18
• 期：5
• 页码：1229-1240
• 全文大小：2279 K
• 卷排序：18

文摘

SIRT7 regulates the acetylation of FKBP51, which then regulates Akt activation Acetylated FKBP51 enhances Akt activity by blocking its interaction with PHLPP-Akt SIRT7 deacetylates FKBP51 at two major lysine residues SIRT7 suppresses Akt activation and modulates cell sensitivity to genotoxic agents