Increased homocysteine levels impair reference memory and reduce cortical levels of acetylcholine in a mouse model of vascular cognitive impairment

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• 作者：Kevin Dam^a ; ^{kdam@rockefeller.edu} ; Martina Fü ; chtemeier^a ; ^b ; ^{martina.fuechtemeier@dzne.de} ; Tracy D. Farr^a ; ^{T.Farr@nottingham.ac.uk} ; Philipp Boehm-Sturm^a ; ^{philipp.boehm-sturm@charite.de} ; Marco Foddis^a ; ^{marco.foddis@charite.de} ; Ulrich Dirnagl^a ; ^b ; ^{ulrich.dirnagl@charite.de} ; Olga Malysheva^c ; ^{ovm4@cornell.edu} ; Marie A. Caudill^c ; ^{mac379@cornell.edu} ; Nafisa M. Jadavji^a ; ^d ; ^{nafisa.jadavji@mail.mcgill.ca}
• 关键词：ChAT ; choline acetyltransferase ; CD ; control diet ; FADD ; Folic acid deficient diet ; Hcy ; homocysteine ; MTHFR ; methylenetetrahydrofolate reductase ; VCI ; vascular cognitive impairment
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：321
• 期：Complete
• 页码：201-208
• 全文大小：1483 K
• 卷排序：321

文摘

Mthfr+/− mice fed FADD with microcoils (VCI) had impaired reference memory. All FADD mice had elevated levels of plasma homocysteine. Arterial remodeling was present in Mthfr+/− microcoil mice. Acetylcholine was reduced in FADD microcoil mice.