Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease

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• 作者：Yan Li^a ; Xiaoming Qiang^a ; Li Luo^a ; Xia Yang^a ; Ganyuan Xiao^a ; Qi Liu^b ; Jiachen Ai^b ; Zhenghuai Tan^b ; ^{tanzhh616@163.com} ; Yong Deng^a ; ^{dengyong@scu.edu.cn}
• 关键词：Alzheimer's disease ; Aurone Mannich base derivatives ; Acetylcholinesterase inhibitors ; Aβ aggregation inhibitors ; Multifunctional agents
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：762-775
• 全文大小：1666 K
• 卷排序：126

文摘

Novel aurone Mannich base derivatives were synthesized. Most compounds showed good acetylcholinesterase inhibitory and antioxidant activity. Some compounds exhibited significant inhibition of self- or Cu2+-induced Aβ aggregation. 7d and 7m were the outstanding representatives with good multifunctional properties. Compound 7d was more excellent than donepezil and showed neuroprotective effect.